Akademik Veri Yönetim Sistemi
Tezin Türü: Yüksek Lisans
Tezin Yürütüldüğü Kurum: Marmara Üniversitesi, Sağlık Bilimleri Enstitüsü, Türkiye
Tezin Onay Tarihi: 2025
Tezin Dili: İngilizce
Öğrenci: ABDUL HAMID
Danışman: Hatice Kübra Elçioğlu
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Özet:
Objective: The purpose of this study is to investigate the pharmacological properties of Thymus longicaulis subsp. longicaulis var. subisophyllus (TL) and Daphne oleoides subsp. oleoides (DO) on acute inflammation in Sprague Dawley rats with carrageenan-induced paw edema. On top of that, this work also focuses on revealing the unfounded scientific factors regarding the two plants mentioned. Moreover, the study also aims to provide a literature review contribution for future studies. At the same time, the results gained by evaluating the assays of the two plants will assist in carrying out new experiments in the upcoming.
Materials and Methods: This study used thirty Sprague Dawley rats for the acute inflammation tests. The carrageenan was applied to induce paw edema, and the indomethacin drug was used as a standard medicine. Petroleum ether, chloroform, ethyl acetate, and methanol extracts of Thymus longicaulis and Daphne oleoides are acquired respectively by maceration methods. The rats were divided into five groups, each group containing six rats. The volume and duration of edema development were determined by using a digital machine called a plethysmometer.
Result: By observing the results obtained from the experiments, the plant extract of Thymus longicaulis and Daphneoleoides exhibited a protective effect on acute inflammation. The TL extract demonstrated a prominent difference every hour in lowering the size of the edema by nearly 10% than the DO extract compared with the standard drug indomethacin.
Conclusion: By analyzing data acquired from the tests the Thymus longicaulis plant extract showed a significant effect (p<0.001) on the protection of acute inflammation than the plant extract of Daphne oleoides. However, there are still gaps in investigating the different parts of the plants with various solvents and examining the responsible phytochemical compounds for the specific pharmacological effects. Nevertheless, further research studies will be required by animal models to determine the mechanism of action, dosage forms, and toxicity study of the extracts before submitting them for clinical trials.
Keywords: Thymus longicaulis, Daphne oleoides, Inflammation, Paw Edema