The protective effects of <i>Myrtus communis</i> subsp. on ovariectomized diabetic rats' renal and intestinal tissues: <i>in vivo</i> and <i>in silico</i> approaches

Ertik O., Kadıoğlu-Yaman B., ŞEN A., Şener G., YANARDAĞ R.

ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY, cilt.131, sa.2, ss.210-226, 2025 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 131 Sayı: 2
  • Basım Tarihi: 2025
  • Doi Numarası: 10.1080/13813455.2024.2406895
  • Dergi Adı: ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.210-226
  • Anahtar Kelimeler: Myrtus communis, diabetes, oxidative stress, ovariectomize, in silico
  • Marmara Üniversitesi Adresli: Evet

Özet

Introduction: Postmenopausal diabetes is a condition that affects millions of women and their quality of life. Also, kidney and small intestine tissues are damaged due to diabetes. The present study aimed to examine the protective effects of an extract prepared from Myrtus communis leaves on kidney and small intestine tissues against experimentally created postmenopausal diabetes. Methods: For this purpose, experimental rats were randomly divided into six groups (Control; ovariectomy:OVX, diabetic:D, ovariectomy + diabetic:OVX + D, ovariectomy + diabetic + oestrogen:OVX + D+E2, ovariectomy + diabetic + MC: OVX + D+MC) and kidney and small intestine tissues were taken after the experimental procedure. Results: Evaluations of biochemical parameters (glutathione and glutathione-related enzymes, antioxidant enzymes, etc.) showed that MC had a protective effect on kidney and small intestine tissues in diabetes and ovariectomy groups. Conclusion: It can be suggested that MC extract has a protective effect on small intestine and kidney tissues in postmenopausal diabetes and may be a good herbal source for this purpose.