The relationship between UGT1A4 polymorphism and serum concentration of lamotrigine in patients with epilepsy

GÜLÇEBİ İDRİZ OĞLU M. , Ozkaynakci A., GÖREN M. Z. , Aker R. , ÖZKARA Ç., ONAT F.

EPILEPSY RESEARCH, cilt.95, ss.1-8, 2011 (SCI İndekslerine Giren Dergi) identifier


Lamotrigine (LTG) which has a widespread use in epilepsy treatment as an antiepileptic agent is metabolized by UDP-glucuronosyl transferase (UGT) enzymes. In this study, single nucleotide polymorphisms, P24T and L48V, of the UGT1A4 enzyme have been investigated in a Turkish population of patients with epilepsy (n=131) by comparing serum levels of LTG of wild type and polymorphic subjects.