The relationship between UGT1A4 polymorphism and serum concentration of lamotrigine in patients with epilepsy

GÜLÇEBİ İDRİZ OĞLU M., Ozkaynakci A., GÖREN M. Z., Aker R., ÖZKARA Ç., ONAT F.

EPILEPSY RESEARCH, cilt.95, ss.1-8, 2011 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 95
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.eplepsyres.2011.01.016
  • Dergi Adı: EPILEPSY RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1-8
  • Anahtar Kelimeler: Lamotrigine, Genetic polymorphism, Glucuronidation, Pharmacogenomics, Pharmacotherapy, ANTIEPILEPTIC DRUGS, GLUCURONIDATION, PHARMACOKINETICS, PREGNANCY, POPULATION, PLASMA
  • Marmara Üniversitesi Adresli: Evet

Özet

Lamotrigine (LTG) which has a widespread use in epilepsy treatment as an antiepileptic agent is metabolized by UDP-glucuronosyl transferase (UGT) enzymes. In this study, single nucleotide polymorphisms, P24T and L48V, of the UGT1A4 enzyme have been investigated in a Turkish population of patients with epilepsy (n=131) by comparing serum levels of LTG of wild type and polymorphic subjects.