Synthesis of highly functionalized gamma-lactones via 1,5-electrocyclic ring closure

Anac O., Kışkan F. Ş., Merey G.

HELVETICA CHIMICA ACTA, cilt.89, sa.6, ss.1231-1240, 2006 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 89 Sayı: 6
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1002/hlca.200690120
  • Dergi Adı: HELVETICA CHIMICA ACTA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1231-1240
  • Marmara Üniversitesi Adresli: Hayır

Özet

We have investigated 1,5-electrocyclic ring-closure reactions of conjugated esters with dimethyl diazomalonate in the presence of [Cu(acac)(2)] as catalyst. Our new protocol offers an easy entry to various polyfunctionalized gamma-lactones in high yields. Their subsequent derivatives may be used as valuable intermediates, especially in the synthesis of natural products and their analogues.