The role of the substantia nigra pars reticulata in kindling resistance in rats with genetic absence epilepsy

Akman O., GÜLÇEBİ İDRİZ OĞLU M., Carcak N., Ozatman S. K., Eryigit T., Moshe S. L., ...Daha Fazla

EPILEPSIA, cilt.56, sa.11, ss.1793-1802, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 56 Sayı: 11
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1111/epi.13204
  • Dergi Adı: EPILEPSIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1793-1802
  • Anahtar Kelimeler: GAERS, Kindling resistance, Substantia nigra pars reticulata, Tyrosine hydroxylase, Parvalbumin, DEVELOPMENTAL REGULATION, TYROSINE-HYDROXYLASE, GABA(A) RECEPTOR, WAVE DISCHARGES, BASAL GANGLIA, SEIZURES, NEURONS, MICROINFUSIONS, ORGANIZATION, STIMULATION
  • Marmara Üniversitesi Adresli: Evet

Özet

ObjectiveGenetic Absence Epilepsy Rats from Strasbourg (GAERS) show a resistance to secondary generalization of focal limbic seizures evoked by kindling. The substantia nigra pars reticulata (SNR) is involved in the propagation and modulation of seizures in kindling. We first examined the role of the SNRanterior and SNRposterior subregions in the resistance to the development of kindling in GAERS. Subsequently, to determine whether kindling resistance relates to differential sensitivity of -aminobutyric acid -aminobutyric acid (GABA)ergic or dopaminergic SNR neurons to kindling, we studied the effects of kindling-inducing stimulations on parvalbumin (PRV; GABAergic neuron marker) or tyrosine hydroxylase (TH; dopaminergic neuron marker) immunoreactivity (ir), respectively, in GAERS and in nonepileptic control (NEC) Wistar rats that lack kindling resistance.