Effect of intravenous immunoglobulin on steroid consumption in patients with severe asthma: A double-blind, placebo-controlled, randomized trial

Salmun L., Barlan I., Wolf H., Eibl M., Twarog F., Geha R., ...More

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol.103, no.5, pp.810-815, 1999 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 103 Issue: 5
  • Publication Date: 1999
  • Doi Number: 10.1016/s0091-6749(99)70424-0
  • Journal Name: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.810-815
  • Keywords: asthma, intravenous immunoglobulin, steroids, LYMPHOCYTE-T ACTIVATION, BRONCHOALVEOLAR LAVAGE, THROMBOCYTOPENIC PURPURA, BRONCHIAL BIOPSIES, KAWASAKI-DISEASE, CHILDHOOD ASTHMA, CELL ACTIVATION, GAMMA-GLOBULIN, ATOPIC ASTHMA, PATHOGENESIS
  • Marmara University Affiliated: No

Abstract

Background: There is a significant group of patients with severe asthma who require chronic use of systemic steroids for control of their disease. These patients are at risk for severe side effects from oral steroids. Intravenous immunoglobulin. (IVIG) has immunomodulatory properties, and a few open-label trials have suggested its possible benefit in individuals with severe asthma.