Effects of topical otic preparations on hearing in chronic otitis media

Ozagar A., Koc A., Ciprut A. A. , Tutkun A., Akdas F., Sehitoglu M.

OTOLARYNGOLOGY-HEAD AND NECK SURGERY, cilt.117, sa.4, ss.405-408, 1997 (SCI İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 117 Konu: 4
  • Basım Tarihi: 1997
  • Doi Numarası: 10.1016/s0194-5998(97)70134-7
  • Sayfa Sayıları: ss.405-408


Most of the topical otic preparations have been shown to cause ototoxicity. In this study ciprofloxacin hydrochloride, a relatively new topical agent, and gentamicin sulfate were studied in two groups of 20 patients with chronic otitis media, Patients were randomly selected to receive either ciprofloxacin (200 mu g/ml) or gentamicin sulfate (5 mg/ml) locally, five drops three times a day for 10 days. Clinical response was seen in 20 of 20 patients in the ciprofloxacin group compared with 6 of 20 patients in the gentamicin group, Audiometric evaluation revealed no significant ototoxic effect in either group, In fact, hearing thresholds were slightly better than pretreatment levels in both groups.