Calm in the midst of cytokine storm: a collaborative approach to the diagnosis and treatment of hemophagocytic lymphohistiocytosis and macrophage activation syndrome


Halyabar O., Chang M. H. , Schoettler M. L. , Schwartz M. A. , Baris E. H. , Benson L. A. , ...Daha Fazla

PEDIATRIC RHEUMATOLOGY, cilt.17, 2019 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1186/s12969-019-0309-6
  • Dergi Adı: PEDIATRIC RHEUMATOLOGY

Özet

Hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) were historically thought to be distinct entities, often managed in isolation. In fact, these conditions are closely related. A collaborative approach, which incorporates expertise from subspecialties that previously treated HLH/MAS independently, is needed. We leveraged quality improvement (QI) techniques in the form of an Evidence-Based Guideline (EBG) to build consensus across disciplines on the diagnosis and treatment of HLH/MAS.