Dendritic Changes of Striatal Neurons in Parkinsonian Rats

Gergin S., Kirazlı Ö. , Boracı H. , Yıldız S. D. , Şehirli Ü. S.

APICA, Busan, South Korea, 28 - 31 October 2018, pp.228-229

  • Publication Type: Conference Paper / Summary Text
  • City: Busan
  • Country: South Korea
  • Page Numbers: pp.228-229


Objectives:Parkinson’s disease (PD) is the second most common neurodegenerative disease which is charecterized by the loss of dopaminergic neurons found within the substantia nigra pars compacta and striatum. Neurodegenerative disorders are mainly caused by oxidative damage. Melatonin is an indole which has been shown to have potent endogenous antioxidant actions. Beside the medical treatment, the physical therapy programmes are being involved as one of the mainstay in the treatment options.


Method:6-OHDA is injected unilaterally to the medial forebrain bundle of Wistar rats (n=48) by stereotaxic method. Rats are divided into eight groups; PD-four and Sham-four groups (vehicle-SF injection). These four groups are; melatonin, swimming exercise, both melatonin and swimming exercise and sedentary. Melatonin injection is applied intraperitonally (30 days).

Results:The number of rotations of both melatonin and exercise groups were found to be less when compared to the sedentary group with a statistically significant difference. Dendiritic spine types were defined in all groups by neurolucida analyze system. Stubby types which are related with degeneration decrease in PD group with melatonin and swimming exercise. Whereas thin type spines were increased in PD group with swimming exercise prominently compared other groups.

Conclusion: Our study managed to verify the hypothesis by demonstrating the neuroprotective effects of the exercise and melatonin. We would like to show a direction to the further clinical studies which could be done in order to show the effects of prolonged periods of exercise and melatonin in PD treatment.