Solubilization of Insoluble and Poorly-Water Soluble Drugs in Micellar Systems

Göktürk S., Toprak C.

Pharmedicine Journal , cilt.1, sa.2, ss.74-84, 2024 (Hakemli Dergi)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 1 Sayı: 2
  • Basım Tarihi: 2024
  • Doi Numarası: 10.62482/pmj.9
  • Dergi Adı: Pharmedicine Journal
  • Sayfa Sayıları: ss.74-84
  • Marmara Üniversitesi Adresli: Evet

Özet

Introduction:This study investigates the micellar solubilization of several insoluble and poorly soluble  drugs—clopidogrel bisulfate, ganciclovir sodium,  miconazole nitrate, brinzolamide, brimonidine  tartarate, and  dexamethasone—using sodium dodecyl  sulfate (SDS),  aerosol-OT (AOT), dodecyl  trimethylammonium bromide (DTAB),  and  cetyltrimethylammonium bromide (CTAB) as surfactants.Methods: The micellar solubilization experiments were conducted by preparing solutions of the drugs in the presence of SDS, AOT, D  TAB, and CTAB micelles. Spectrophotometric measurements were performed at a constant temperature of 298 K to analyze the solubilization efficiency of each surfactant. Phase-solubilization graphs were plotted to  visualize the relationship between drug solubility and surfactant concentration.Results:  The  results indicated that    hydrophobic interactions play a  critical role in  surfactant solubilization powe r. AOT was   identified as  the most effective surfactant among those tested. The  solubility  tendencies  of  the  drugs  in  the  presence  of  micelles  were  discussed  based  on the calculated  KM values and the spectral behavior of drug molecules.Conclusion: Micellar solubilization offers a promising approach to characterize drugs with varying solubility  profiles—ranging from slightly soluble  to insoluble  in  water.  Additionally,  surfactant micelles serve as effective biomimetic models for membrane systems in pharmaceutical research. the  findings from this study hold implications for drug formulation and design, particularly in addressing solubilization challenges and optimizing pharmaceutical dosage forms.Keywords: Surfactant, poorly soluble drugs, critical micelle concentration, micelle, solubilizationOriginal ArticleSolubilization of Insoluble and Poorly-Water Soluble Drugs in Micellar SystemsSinem Gokturk1✉,   Cuneyt Toprak1,2¹Marmara University, Faculty of Pharmacy, Department of Basic Pharmaceutical Sciences İstanbul, Türkiye2 Marmara University, Institute of Health Sciences, Pharmaceutical Basic Sciences, İstanbul, Türkiye✉Corresponding Author: Sinem GÖKTÜRK (E-mail: sgokturk@marmara.edu.tr)Received: 2024.04.02; Revised: 2024.06.03; Accepted: 2024.06.06