Akademik Veri Yönetim Sistemi
Applications of Chemistry in Nanosciences and Biomaterials Engineering NanoBioMat 2025 – Winter Edition, Bucuresti, Romanya, 26 - 28 Kasım 2025, ss.72-74, (Özet Bildiri)
Postoperative adjuvant therapy with GABA-loaded nanofibers aims to mitigate neurotoxicity, inflammation, and tissue damage often associated with postoperative complications, particularly in cancer treatment contexts where chemotherapeutic agents may exacerbate neural and tissue injury. The localized delivery system minimizes systemic exposure, potentially reducing side effects and improving patient outcomes by promoting tissue regeneration and neuroprotective effects [1]. This study focuses on the development of gamma-aminobutyric acid (GABA)-loaded nanofibers as a novel approach for postoperative adjuvant therapy. GABA, a key inhibitory neurotransmitter with known neuroprotective and anti-inflammatory effects, has been encapsulated within biocompatible nanofibrous scaffolds designed for localized, sustained drug release at surgical sites. The synthesis of these nanofibers employed electrospinning techniques using polymers optimized to maintain GABA stability while facilitating controlled release over an extended period. GABA was successfully incorporated into nanofibers fabricated via electrospinning, using a blend of poly(lactic acid) (PLA) and polyvinylpyrrolidone (PVP). Electrospun PLA/PVP/GABA nanofibers were characterized by scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FT-IR), thermal analysis (DSC), and tensile strength. Scanning SEM confirmed the formation of smooth, continuous nanofibers. FTIR spectroscopy analyses verified the successful incorporation of GABA into the polymer matrix and indicated an amorphous dispersion of the drug [2,3]. In conclusion, we have successfully engineered a biocompatible and biodegradable GABA-loaded nanofiber system. The study highlights the promise of GABA-loaded nanofibers as an innovative platform for improving postoperative healing and recovery by harnessing the therapeutic benefits of GABA while leveraging the advantages of nanofiber drug delivery technology [4].