Regulation of M-2, M-3, and M-4 muscarinic receptor expression in K562 chronic myelogenous leukemic cells by carbachol

Cabadak H., Aydın B., Kan B.

JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION, cilt.31, ss.26-32, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31
  • Basım Tarihi: 2011
  • Doi Numarası: 10.3109/10799893.2010.506484
  • Dergi Adı: JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.26-32
  • Anahtar Kelimeler: Agonist, cell proliferation, mRNA regulation, INDUCED DOWN-REGULATION, CEREBELLAR GRANULE CELLS, MESSENGER-RNA EXPRESSION, ACETYLCHOLINE-RECEPTOR, CHOLINERGIC SYSTEM, DNA-SYNTHESIS, SUBTYPES, LINE, ACTIVATION, IDENTIFICATION
  • Marmara Üniversitesi Adresli: Evet

Özet

Context: Muscarinic receptors mediate a variety of cellular responses to acetylcholine, including inhibition of adenylate cyclase, breakdown of phosphoinositide and modulation of ion channels. These receptors are relatively abundant in the central nervous system and peripheral parasympathetic nervous system. Many cells express a mixture of muscarinic receptor transcripts. Changes in muscarinic M-2 and M-3 receptor mRNA levels in response to agonist treatment have been reported in cerebellar granule cells, Chinese hamster ovary cells, lymphocytes and in the human neuroblastoma cell line SH-SY5Y.