Recent advances bioactive 1,2,4-triazole-3-thiones

KÜÇÜKGÜZEL Ş. G. , Cikla-Suzgun P.

European Journal of Medicinal Chemistry, cilt.97, sa.1, ss.830-870, 2015 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 97 Konu: 1
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1016/j.ejmech.2014.11.033
  • Dergi Adı: European Journal of Medicinal Chemistry
  • Sayfa Sayıları: ss.830-870


Triazoles are heterocyclic compounds which have a five-membered ring of two carbon atoms and three nitrogen atoms. These structures have been interest in the development of novel compounds with anticonvulsant, antidepressant, antioxidant, anti-inflammatory, analgesic, antinociceptive, antibacterial, antimycobacterial, antifungal, antiviral, anticancer, anti-parasitic, anti-urease and other activities. Therefore, many researchers have synthesized these compounds as target structures and evaluated their biological activities. This review contains various pharmacological activities of 1,2,4-triazole-3-thiones in one place and it is also the milestone for the new research towards this moiety. (C) 2014 Elsevier Masson SAS. All rights reserved.