Analysis of histopathological and clinical prognostic factors in lymphomas involving the gastrointestinal system
World Journal of Gastrointestinal Oncology, cilt.18, sa.3, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 18 Sayı: 3
- Basım Tarihi: 2026
- Doi Numarası: 10.4251/wjgo.v18.i3.115912
- Dergi Adı: World Journal of Gastrointestinal Oncology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE
- Anahtar Kelimeler: Gastric lymphoma, Gastrointestinal system, Intestinal lymphoma, Lymphoma
- Marmara Üniversitesi Adresli: Evet
Özet
BACKGROUND Primary gastrointestinal lymphomas (PGIL) are rare tumors that can involve the whole gastrointestinal (GI) tract. Although lymphomas can originate from any part of the gastrointestinal tract, the most common sites are the stomach, small intestine, and ileocecal region. AIM To examine the clinicopathologic and prognostic features of PGIL. METHODS We performed a retrospective single-center analysis of 111 patients diagnosed with gastrointestinal lymphomas (GIL) at Izmir Katip Celebi University Ataturk Training and Research Hospital. Histopathological, clinical, and prognostic para-meters, including pathological subtype, Helicobacter pylori infection, tumor stage, grade, Performance Score (PS), International Prognostic Index, lactate dehydrogenase (LDH) level, and treatment modality of PGILs (2006-2018), were retro-spectively analyzed using SPSS 25.0. RESULTS The study included 111 patients diagnosed with GIL. The median age was 66 years (60 males, 51 females). Sites of involvement were stomach (67.5%), small bowel (18%), large bowel/rectum (12.6%), and pancreas (1.8%). Among 62 patients with primary GIL, 49 (79%) had diffuse large B-cell lymphoma (DLBCL), 6 (9.7%) had extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue, 2 (3.2%) had mantle cell lymphoma, 2 (3.2%) had unclassified B-cell lymphoma, and 2 (3.2%) had T-cell lymphoma. The 1-, 3-, and 5-year overall survival (OS) and event-free survival rates were 67%, 56%, 47%, and 80%, 58.6%, 54.4%, respectively. In univariate analysis, LDH level (LDH ≥ 270 U/L) (P = 0.029), PS [Eastern Cooperative Oncology Group (ECOG) ≥ 2] (P < 0.0001), and surgical treatment (P = 0.002) were associated with survival. In multivariate analysis, a poor PS (ECOG ≥ 2) (P = 0.010) was an independent predictor of poor OS. CONCLUSION In this study, the stomach was the most frequently involved site, DLBCL was the predominant subtype, and poor performance status was associated with poorer survival.