Antidepressant-like Effects Induced by Chronic Blockade of the Purinergic 2X7 Receptor through Inhibition of Non-like Receptor Protein 1 Inflammasome in Chronic Unpredictable Mild Stress Model of Depression in Rats


ARICIOĞLU F. , Ozkartal C. S. , Bastaskin T., Tuzun E., Kandemir C., ŞİRVANCI S. , ...Daha Fazla

CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE, cilt.17, sa.2, ss.261-272, 2019 (SCI İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Konu: 2
  • Basım Tarihi: 2019
  • Doi Numarası: 10.9758/cpn.2019.17.2.261
  • Dergi Adı: CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
  • Sayfa Sayıları: ss.261-272

Özet

Objective: Purinergic 2X7 receptor (P2X7R) activation is known to be involved in pathogenesis of depression. Our aims were to investigate P2X7R-activated inflammasome pathways in parallel with induction of depression and to test the antidepressant-like effects of the selective P2X7R antagonist Brilliant Blue G (BBG) in a rat model of chronic unpredictable mild stress (CUMS).