Oral bisphosphonate therapy for vitamin D intoxication of the infant

Bereket A. , Erdogan T.

PEDIATRICS, cilt.111, sa.4, ss.899-901, 2003 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 111 Konu: 4
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1542/peds.111.4.899
  • Dergi Adı: PEDIATRICS
  • Sayfa Sayıları: ss.899-901


Vitamin D intoxication in infancy has serious consequences attributable to acute hypercalcemia and subsequent hypercalcuria/nephrocalcinosis. Current treatments of patients with vitamin D intoxication are unsatisfactory and associated with prolonged hypercalcemia. We now report the use of oral alendronate sodium in a 3-month-old infant with vitamin D intoxication. Short-term oral alendronate sodium treatment effectively corrected hypercalcemia/hypercalciuria, decreased the duration of hospitalization, and appears safe in 15 months of observation.