A Hybrid Bayesian Network Framework for Risk Assessment of Arsenic Exposure and Adverse Reproductive Outcomes

Orak N. H.

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, cilt.192, 2020 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 192
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.ecoenv.2020.110270
  • Dergi Adı: ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, Aerospace Database, Aqualine, Aquatic Science & Fisheries Abstracts (ASFA), Artic & Antarctic Regions, BIOSIS, CAB Abstracts, Chemical Abstracts Core, Chimica, Communication Abstracts, EMBASE, Environment Index, Food Science & Technology Abstracts, Geobase, Greenfile, MEDLINE, Metadex, Pollution Abstracts, Veterinary Science Database, Civil Engineering Abstracts
  • Anahtar Kelimeler: Arsenic exposure, Maternal, Low birthweight, Bayesian networks, Risk analysis, BIOMARKERS
  • Marmara Üniversitesi Adresli: Evet

Özet

Arsenic contamination of drinking water affects more than 137 million people and has been linked to several adverse health effects. The traditional toxicological approach, "dose-response" graphs, are limited in their ability to unveil the relationships between potential risk factors of arsenic exposure for adverse human health outcomes, which are critically important to understanding the risk at low exposure levels of arsenic. Therefore, to provide insight on the potential interactions of different variables of the arsenic exposure network, this study characterizes the risk factors by developing a hybrid Bayesian Belief Network (BBN) model for health risk assessment. The results show that the low inorganic arsenic concentration increases the risk of low birth weight even for low gestational age scenarios. While increasing the mother's age does not increase the low birthweight risk, it affects the distribution between other categories of baby weight. For low MMA% ( < 4%) in the human body, increasing gestational age decreases the risk of having low birthweight. The proposed BBN model provides 82% sensitivity and 72% specificity in average for different states of birthweight.