Silymarin, the Antioxidant Component of Silybum marianum, Prevents Sepsis-Induced Acute Lung and Brain Injury

Toklu H. Z. , Akbay T. , Velioglu-Ogunc A. , Ercan F. , Gedik N., Keyer-Uysal M., ...Daha Fazla

Journal of Surgical Research, cilt.145, ss.214-222, 2008 (SCI Expanded İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 145 Konu: 2
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.jss.2007.03.072
  • Dergi Adı: Journal of Surgical Research
  • Sayfa Sayıları: ss.214-222

Özet

Background. Sepsis is associated with enhanced generation of reactive oxygen species, which leads to multiple organ dysfunctions. Based on the potent antioxidant effects of silymarin, we investigated the putative protective role of silymarin against sepsis-induced oxidative damage in lung and brain tissues.