Silymarin, the Antioxidant Component of Silybum marianum, Prevents Sepsis-Induced Acute Lung and Brain Injury

Toklu H. Z., Akbay T., Velioglu-Ogunc A., Ercan F., Gedik N., Keyer-Uysal M., ...Daha Fazla

Journal of Surgical Research, cilt.145, sa.2, ss.214-222, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 145 Sayı: 2
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.jss.2007.03.072
  • Dergi Adı: Journal of Surgical Research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.214-222
  • Anahtar Kelimeler: silybum marianum, silymarin, sepsis, antioxidant, cytokine, myeloperoxidase, glutathione, N-acetylcysteine, lung, brain, TISSUE FACTOR, MILK THISTLE, MOUSE SKIN, RAT-LIVER, MODEL, MYELOPEROXIDASE, COAGULATION, KINASE, KIDNEY, CELLS
  • Marmara Üniversitesi Adresli: Evet

Özet

Background. Sepsis is associated with enhanced generation of reactive oxygen species, which leads to multiple organ dysfunctions. Based on the potent antioxidant effects of silymarin, we investigated the putative protective role of silymarin against sepsis-induced oxidative damage in lung and brain tissues.