In vivo inefficiency of pentoxifylline and interferon-alpha on hepatic fibrosis in biliary-obstructed rats: assessment by tissue collagen content and prolidase activity.

Tarcin O., Avsar K., Demirturk L., Gultepe M., Oktar B., Ozdogan O. C., ...More

Journal of gastroenterology and hepatology, vol.18, no.4, pp.437-44, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18 Issue: 4
  • Publication Date: 2003
  • Doi Number: 10.1046/j.1440-1746.2003.03004.x
  • Journal Name: Journal of gastroenterology and hepatology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.437-44
  • Keywords: antifibrotic, bile duct ligation, combination, hepatic fibrosis, interferon-alpha, pentoxifylline, prolidase, rat, BILE-DUCT OBSTRUCTION, LIVER FIBROSIS, QUANTITATIVE ASSESSMENT, HISTOLOGICAL ACTIVITY, MORPHOMETRIC METHOD, EXPERIMENTAL-MODEL, PLASMA PROLIDASE, SCORING SYSTEM, SERUM MARKERS, C PATIENTS
  • Marmara University Affiliated: Yes

Abstract

Background and Aim: To evaluate the possible antifibrotic effects of two drugs, pentoxifylline (PTX) and interferon (IFN)-alpha as well as their combination, on a bile-duct-ligated rat hepatic fibrosis model.