Effects of Deeper Molecular Responses on Outcomes in Chronic Myeloid Leukemia Patients in Chronic Phase Treated With Imatinib Mesylate

ATAGÜNDÜZ, IŞIK; TOPTAŞ, TAYFUR; Deniz, Rabia; Kara, Osman; Eser, All; Sezgin, Aslihan; Ozgumus, Toluy; Gecgel, Fatma; Tuglularl, Tulin

doi:10.1016/j.clml.2016.09.006

Effects of Deeper Molecular Responses on Outcomes in Chronic Myeloid Leukemia Patients in Chronic Phase Treated With Imatinib Mesylate

Atıf İçin Kopyala

ATAGÜNDÜZ I., TOPTAŞ T., Deniz R., Kara O., Eser A., Sezgin A., ...Daha Fazla

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, cilt.17, sa.2, ss.120-125, 2017 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 17 Sayı: 2
Basım Tarihi: 2017
Doi Numarası: 10.1016/j.clml.2016.09.006
Dergi Adı: CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.120-125
Marmara Üniversitesi Adresli: Evet

Özet

The significance of molecular response depth is not well defined in patients with chronic phase chronic myeloid leukemia (CP-CML) under imatinib treatment. We retrospectively evaluated clinical records of 178 patients with CP-CML. Eighty-eight patients achieved complete molecular response during long term follow-up. Our results implicate that deeper molecular response is associated with improvement in disease outcome and a slight prolongation in progression-free survival.