Effects of Deeper Molecular Responses on Outcomes in Chronic Myeloid Leukemia Patients in Chronic Phase Treated With Imatinib Mesylate


ATAGÜNDÜZ I. , TOPTAŞ T. , Deniz R., Kara O., Eser A., Sezgin A., et al.

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, cilt.17, ss.120-125, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 17 Konu: 2
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.clml.2016.09.006
  • Dergi Adı: CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
  • Sayfa Sayısı: ss.120-125

Özet

The significance of molecular response depth is not well defined in patients with chronic phase chronic myeloid leukemia (CP-CML) under imatinib treatment. We retrospectively evaluated clinical records of 178 patients with CP-CML. Eighty-eight patients achieved complete molecular response during long term follow-up. Our results implicate that deeper molecular response is associated with improvement in disease outcome and a slight prolongation in progression-free survival.