Serum osteoprotegerin levels, endothelial function and carotid intima-media thickness in type 2 diabetic patients

Gunes M., Temizkan S., Apaydin T., Ilgin C., Haklar G., Gogas Yavuz D.

JOURNAL OF DIABETES AND ITS COMPLICATIONS, vol.35, no.12, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 12
  • Publication Date: 2021
  • Doi Number: 10.1016/j.jdiacomp.2021.108073
  • Journal Name: JOURNAL OF DIABETES AND ITS COMPLICATIONS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CINAHL, EMBASE, MEDLINE
  • Keywords: Type 2 diabetes mellitus, Osteoprotegerin, Flow-mediated dilation, Endothelial function, Carotid intima-media thickness, VASCULAR CALCIFICATION, PLASMA OSTEOPROTEGERIN, MYOCARDIAL-INFARCTION, PREDICTIVE-VALUE, ARTERY-DISEASE, TASK-FORCE, ATHEROSCLEROSIS, DYSFUNCTION, RISK, VASODILATION
  • Marmara University Affiliated: Yes

Abstract

Objectives: Osteoprotegerin (OPG), a well-known protein that inhibits osteoclast formation and activity, might also be a potential marker for identifying patients with high cardiovascular risk. This study aimed to compare OPG levels, FMD, and CIMT measurements in subjects with vs. without diabetes and investigate the association of serum osteoprotegerin level with the early atherosclerotic markers, endothelial function, and carotid intimamedia thickness (CIMT) in patients with type 2 diabetes mellitus (DM2).