Interleukin-2, interleukin-6 and T regulatory cells in peripheral blood of patients with Behcet's disease and recurrent aphthous ulcerations

PEKİNER F. M., AYTUGAR E., Demirel G. Y., BORAHAN M. O.

JOURNAL OF ORAL PATHOLOGY & MEDICINE, cilt.41, sa.1, ss.73-79, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 41 Sayı: 1
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1111/j.1600-0714.2011.01061.x
  • Dergi Adı: JOURNAL OF ORAL PATHOLOGY & MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.73-79
  • Anahtar Kelimeler: Behcet's disease, cytokine, IL-2, IL-6, recurrent aphthous ulcerations, T regulatory cell, NECROSIS-FACTOR-ALPHA, IMMUNOLOGICAL-TOLERANCE, TNF-ALPHA, EXPRESSION, CYTOKINES, IL-6, RECEPTOR, LESIONS, FOXP3, GAMMA
  • Marmara Üniversitesi Adresli: Evet

Özet

BACKGROUND: One of the factors involved in the pathogenesis of Behcet disease (BD) and recurrent aphthous ulcerations (RAU) is a cell-mediated immune response in which several cytokines (interleukin-2, interleukin-6) and T regulatory cell (T reg cell) population seem to play a major role. The aim of this study was to measured the interleukin-2 (IL-2), interleukin-6 (IL-6) levels and analysis of CD4(+) CD25(+) Foxp-3(+) Treg cells in peripheral blood from patients with BD and RAU. In addition; we also analysed peripheral blood from healthy subjects for comparison.