Engineering of a novel SilkMA-bacterial cellulose hydrogel bioink for digital light processing three-dimensional bioprinting

Baykara D., YILMAZ Ö., Avci T., Ilhan E., Yildirim R., Egles C., ...Daha Fazla

MRS Bulletin, 2026 (SCI-Expanded, Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Basım Tarihi: 2026
  • Doi Numarası: 10.1557/s43577-025-01023-5
  • Dergi Adı: MRS Bulletin
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Compendex, INSPEC
  • Anahtar Kelimeler: Bacterial cellulose, DLP 3D printing, Methacrylated silk fibroin, Tissue engineering
  • Marmara Üniversitesi Adresli: Evet

Özet

Abstract: In this study, a novel composite bioink composed of methacrylated silk fibroin (SilkMA) and bacterial cellulose (BC) hydrogels was fabricated by digital light processing (DLP)-based three-dimensional bioprinting. Various structural designs were successfully fabricated using the DLP technique, and the resulting constructs were systematically characterized in terms of their chemical composition, morphology, mechanical properties, swelling behavior, and degradation profile. Scanning electron microscopy analyses revealed interconnected porous architectures, essential for tissue-engineering applications. The incorporation of BC into the SilkMA matrix significantly enhanced the mechanical strength of the hydrogels. In vitro biocompatibility was assessed using human dermal fibroblast cells, demonstrating favorable cell attachment and proliferation with no observed cytotoxic effects. Overall, the results highlight the potential of DLP-printed SilkMA/BC hydrogels as a promising and tunable bioink for biomedical applications.