Lowering Uric Acid With Allopurinol Improves Insulin Resistance and Systemic Inflammation in Asymptomatic Hyperuricemia

Takir M., Kostek O., Ozkok A., ELÇİOĞLU Ö. C., Bakan A., Erek A., ...Daha Fazla

JOURNAL OF INVESTIGATIVE MEDICINE, cilt.63, sa.8, ss.924-929, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 63 Sayı: 8
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1097/jim.0000000000000242
  • Dergi Adı: JOURNAL OF INVESTIGATIVE MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.924-929
  • Anahtar Kelimeler: uric acid, allopurinol, insulin resistance, inflammation, EXCESSIVE FRUCTOSE INTAKE, METABOLIC SYNDROME, OXIDATIVE STRESS, GLOMERULAR HYPERTENSION, POTENTIAL-ROLE, FATTY-LIVER, GLUCOSE, OBESITY, SIGNAL, RATS
  • Marmara Üniversitesi Adresli: Hayır

Özet

Background Hyperuricemia is an independent predictor of impaired fasting glucose and type 2 diabetes, but whether it has a causal role in insulin resistance remains controversial. Here we tested the hypothesis that lowering uric acid in hyperuricemic nondiabetic subjects might improve insulin resistance.