Lowering Uric Acid With Allopurinol Improves Insulin Resistance and Systemic Inflammation in Asymptomatic Hyperuricemia

---

Takir M., Kostek O., Ozkok A., ELÇİOĞLU Ö. C., Bakan A., Erek A., ...Daha Fazla

JOURNAL OF INVESTIGATIVE MEDICINE, cilt.63, sa.8, ss.924-929, 2015 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 63 Sayı: 8
• Basım Tarihi: 2015
• Doi Numarası: 10.1097/jim.0000000000000242
• Dergi Adı: JOURNAL OF INVESTIGATIVE MEDICINE
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Sayfa Sayıları: ss.924-929
• Anahtar Kelimeler: uric acid, allopurinol, insulin resistance, inflammation, EXCESSIVE FRUCTOSE INTAKE, METABOLIC SYNDROME, OXIDATIVE STRESS, GLOMERULAR HYPERTENSION, POTENTIAL-ROLE, FATTY-LIVER, GLUCOSE, OBESITY, SIGNAL, RATS
• Marmara Üniversitesi Adresli: Hayır

Özet

Background Hyperuricemia is an independent predictor of impaired fasting glucose and type 2 diabetes, but whether it has a causal role in insulin resistance remains controversial. Here we tested the hypothesis that lowering uric acid in hyperuricemic nondiabetic subjects might improve insulin resistance.