Co-production of levan with other high-value bioproducts: A review

de Siqueira E. C., TOKSOY ÖNER E.

International Journal of Biological Macromolecules, cilt.235, 2023 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 235
  • Basım Tarihi: 2023
  • Doi Numarası: 10.1016/j.ijbiomac.2023.123800
  • Dergi Adı: International Journal of Biological Macromolecules
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, Food Science & Technology Abstracts, INSPEC, MEDLINE, Veterinary Science Database
  • Anahtar Kelimeler: Fructan, Levan, Co-production, Fructooligosaccharides, Bioproducts, DIFRUCTOSE ANHYDRIDE IV, BACILLUS-SUBTILIS NATTO, ZYMOMONAS-MOBILIS, SELECTIVE PRODUCTION, LEVANSUCRASE, ETHANOL, FRUCTOOLIGOSACCHARIDES, BIOSYNTHESIS, SUCROSE, FERMENTATION
  • Marmara Üniversitesi Adresli: Evet

Özet

Levan is a homopolysaccharide of fructose that has both scientific and industrial importance, with various applications in health, pharmaceutical, cosmetic and food industries. Despite its broad spectrum of uses, there are only a limited number of commercial levan sources due to the high costs related to its production. To make production economically viable, efforts have been concentrated on the selection of levan-producing microorganisms, the genetic manipulation of new strains, and the use of inexpensive agro-industrial byproducts as substrates. Another efficient strategy involves the concomitant synthesis of other products with high market value and as such, the successful co-production of levan was demonstrated with fructooligosaccharides, ethanol, sorbitol, poly-ε-lysine, poly-γ-glutamic acid and polyhydroxyalkanoates. This paper offers a systematic review of important aspects regarding recent strategies involving the simultaneous synthesis of levan and other bioproducts of aggregate value reported to date and discusses the challenges and opportunities for its large-scale production and applications.