Effects of melatonin on testicular tissue nitric oxide level and antioxidant enzyme activities in experimentally induced left varicocele

Semercioz A., ONUR A. R., Ogras S., Orhan I.

NEUROENDOCRINOLOGY LETTERS, vol.24, pp.86-90, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24
  • Publication Date: 2003
  • Journal Name: NEUROENDOCRINOLOGY LETTERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.86-90
  • Keywords: varicocele, testis, nitric oxide, reactive oxygen species, melatonin, ISCHEMIA-REPERFUSION INJURY, SYNTHASE, ADOLESCENTS, TESTIS, PLASMA, BLOOD, SERUM, RATS
  • Marmara University Affiliated: No

Abstract

OBJECTIVES: The pathophysiology of the testicular damage in varicocele have not been completely understood. There are several studies concerning the effects of increased seminal reactive oxygen species (ROS) and the role of nitric oxide (NO) in infertile patients with varicocele and antioxidants have been used successfully to decrease oxidative stress in testis. In this study, we determined the effects of melatonin on testicular NO and antioxidant enzyme levels and investigated whether melatonin can prevent or diminish testicular damage in adult rats with experimentally induced unilateral varicocele.