Sodium fusidate-poly(D,L-lactide-co-glycolide) microspheres: Preparation, characterisation and in vivo evaluation of their effectiveness in the treatment of chronic osteomyelitis


Cevher E., Orhan Z., Sensoy D., Ahiskali R., Kan P. L. , Sagirli O., ...Daha Fazla

JOURNAL OF MICROENCAPSULATION, cilt.24, ss.577-595, 2007 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 24 Konu: 6
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1080/02652040701472584
  • Dergi Adı: JOURNAL OF MICROENCAPSULATION
  • Sayfa Sayıları: ss.577-595

Özet

Purpose: The aim of this study was to prepare poly(D, L- lactide-co-glycolide) (PLGA) microspheres containing sodium fusidate ( SF) using a double emulsion solvent evaporation method with varying polymer: drug ratios (1: 1, 2.5: 1, 5: 1) and to evaluate its efficiency for the local treatment of chronic osteomyelitis.