Sodium fusidate-poly(D,L-lactide-co-glycolide) microspheres: Preparation, characterisation and in vivo evaluation of their effectiveness in the treatment of chronic osteomyelitis

Cevher E., Orhan Z., Sensoy D., Ahiskali R., Kan P. L., Sagirli O., ...Daha Fazla

JOURNAL OF MICROENCAPSULATION, cilt.24, sa.6, ss.577-595, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 6
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1080/02652040701472584
  • Dergi Adı: JOURNAL OF MICROENCAPSULATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.577-595
  • Anahtar Kelimeler: sodium fusidate, poly(D,L-lactide-co-glycolide) microspheres, emulsion solvent evaporation method, methicillin-resistant Staphylococcus aureus, chronic osteomyelitis, RESISTANT STAPHYLOCOCCUS-AUREUS, CIPROFLOXACIN IMPLANTS, BONE IMPLANTATION, FUSIDIC ACID, LACTIC-ACID, VITRO, MICROPARTICLES, FORMULATION, VANCOMYCIN, SIZE
  • Marmara Üniversitesi Adresli: Evet

Özet

Purpose: The aim of this study was to prepare poly(D, L- lactide-co-glycolide) (PLGA) microspheres containing sodium fusidate ( SF) using a double emulsion solvent evaporation method with varying polymer: drug ratios (1: 1, 2.5: 1, 5: 1) and to evaluate its efficiency for the local treatment of chronic osteomyelitis.