The Gamma-Butyrolactone Model of Absence Epilepsy: Acute and Chronic Effects in Wistar Rats

KARAMAHMUTOĞLU T., Carcak N., ŞAHİNER A. M., Akman O., Snead O. C., Eskazan E., ...Daha Fazla

EPILEPSI, cilt.19, sa.2, ss.48-52, 2013 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 2
  • Basım Tarihi: 2013
  • Doi Numarası: 10.5505/epilepsi.2013.65365
  • Dergi Adı: EPILEPSI
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.48-52
  • Anahtar Kelimeler: Absence epilepsy, gamma-butyrolactone, wistar rats, EEG, HYDROXYBUTYRIC ACID, SEIZURES, MECHANISMS, BRAIN
  • Marmara Üniversitesi Adresli: Evet

Özet

Objectives: We studied the electroencephalographic (EEG) and behavioral changes of the chemical model of generalized absence epilepsy induced by acute and chronic administration of gamma-butrolactone (GBL), a prodrug of gamma-hydroxybutyric acid.