Palmitic acid induces endoplasmic reticulum stress in AML12 liver cells

Demirel T., BATIREL S.

MARMARA MEDICAL JOURNAL, cilt.31, sa.1, ss.40-46, 2018 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31 Sayı: 1
  • Basım Tarihi: 2018
  • Doi Numarası: 10.5472/marumj.362169
  • Dergi Adı: MARMARA MEDICAL JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.40-46
  • Anahtar Kelimeler: Non-alcoholic fatty liver disease, Palmitic acid, Oleic acid, Endoplasmic reticulum stress, NONALCOHOLIC STEATOHEPATITIS, HEPATIC STEATOSIS, MOLECULAR-MECHANISMS, OXIDATIVE STRESS, RAT HEPATOCYTES, APOPTOSIS, CYTOTOXICITY, PATHOGENESIS, ACTIVATION, INDUCTION
  • Marmara Üniversitesi Adresli: Evet

Özet

Objectives: Non-alcoholic fatty liver disease (NAFLD) is characterized by increased fatty acid levels in serum and liver. The mechanism of NAFLD is unclear. The role of endoplasmic reticulum (ER) stress attracts attention. First aim of this study was to design an in vitro NAFLD model. The effects of palmitic acid (PA) alone or combination with oleic acid (OA) on intracellular reactive oxygen species (ROS) production and ER stress in liver cells were investigated as a second aim.