Evidence for the involvement of neuronal nitric oxide synthase and soluble guanylate cyclase on cognitive functions in rats

Komsuoglu-Celikyurt I., GÖÇMEZ S. S., MUTLU O., Gacar N., ARICIOĞLU F., UTKAN T.

LIFE SCIENCES, cilt.89, ss.905-910, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 89
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.lfs.2011.09.017
  • Dergi Adı: LIFE SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.905-910
  • Anahtar Kelimeler: 3-bromo-7-nitroindazole, ODQ, NO, Guanylate cyclase, Working memory, Reference memory, Emotional learning, Rats, LONG-TERM POTENTIATION, MEMORY FORMATION, IMPAIRS RETENTION, PROTEIN-KINASE, INHIBITION, CGMP, MICE, NITRATION, TASK, NEURODEGENERATION
  • Marmara Üniversitesi Adresli: Evet

Özet

Aims: The influence of 3-bromo-7-nitroindazole (3-Br 7-NI), a potent and selective neuronal nitric oxide synthase (nNOS) inhibitor, and [1H-[1,2,4]-oxadiazole[4,3a]-quinoxaline-1-one] (ODQ), a highly selective, irreversible inhibitor of soluble guanylate cyclase (sGC), on working and reference memory and emotional learning was investigated in rats.