Resveratrol improves cardiovascular function and reduces oxidative organ damage in the renal, cardiovascular and cerebral tissues of two-kidney, one-clip hypertensive rats

Toklu, Hale; Sehirli, Ozer; Ersahin, Mehmet; Suleymanoglu, Selami; Yiginer, Omer; Emekli-Alturfan, EBRU; Yarat, AYŞEN; YEGEN, BERRAK; Senser, Goksel

doi:10.1111/j.2042-7158.2010.01197.x

Resveratrol improves cardiovascular function and reduces oxidative organ damage in the renal, cardiovascular and cerebral tissues of two-kidney, one-clip hypertensive rats

Toklu H. Z., Sehirli O., Ersahin M., Suleymanoglu S., Yiginer O., Emekli-Alturfan E. I., ...More

JOURNAL OF PHARMACY AND PHARMACOLOGY, vol.62, no.12, pp.1784-1793, 2010 (SCI-Expanded, Scopus)

Publication Type: Article / Article
Volume: 62 Issue: 12
Publication Date: 2010
Doi Number: 10.1111/j.2042-7158.2010.01197.x
Journal Name: JOURNAL OF PHARMACY AND PHARMACOLOGY
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1784-1793
Keywords: hypertension, Na+/K+-ATPase, oxidative stress, resveratrol, WINE POLYPHENOL RESVERATROL, RENIN-ANGIOTENSIN SYSTEM, RED WINE, SUPEROXIDE-DISMUTASE, LIPID-PEROXIDATION, ENDOTHELIAL DYSFUNCTION, INDUCED CARDIOTOXICITY, VASCULAR DYSFUNCTION, NADPH OXIDASE, CAUSAL ROLE
Marmara University Affiliated: Yes

Abstract

Objectives The putative protective effects of resveratrol against oxidative injury in the heart, kidney and brain tissues of rats induced with the two-kidney, one-clip (2K1C) hypertension model were investigated.