Resveratrol improves cardiovascular function and reduces oxidative organ damage in the renal, cardiovascular and cerebral tissues of two-kidney, one-clip hypertensive rats

Toklu, Hale; Sehirli, Ozer; Ersahin, Mehmet; Suleymanoglu, Selami; Yiginer, Omer; Emekli-Alturfan, EBRU; Yarat, AYŞEN; YEGEN, BERRAK; Senser, Goksel

doi:10.1111/j.2042-7158.2010.01197.x

Resveratrol improves cardiovascular function and reduces oxidative organ damage in the renal, cardiovascular and cerebral tissues of two-kidney, one-clip hypertensive rats

Toklu H. Z., Sehirli O., Ersahin M., Suleymanoglu S., Yiginer O., Emekli-Alturfan E. I., ...Daha Fazla

JOURNAL OF PHARMACY AND PHARMACOLOGY, cilt.62, sa.12, ss.1784-1793, 2010 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 62 Sayı: 12
Basım Tarihi: 2010
Doi Numarası: 10.1111/j.2042-7158.2010.01197.x
Dergi Adı: JOURNAL OF PHARMACY AND PHARMACOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1784-1793
Anahtar Kelimeler: hypertension, Na+/K+-ATPase, oxidative stress, resveratrol, WINE POLYPHENOL RESVERATROL, RENIN-ANGIOTENSIN SYSTEM, RED WINE, SUPEROXIDE-DISMUTASE, LIPID-PEROXIDATION, ENDOTHELIAL DYSFUNCTION, INDUCED CARDIOTOXICITY, VASCULAR DYSFUNCTION, NADPH OXIDASE, CAUSAL ROLE
Marmara Üniversitesi Adresli: Evet

Özet

Objectives The putative protective effects of resveratrol against oxidative injury in the heart, kidney and brain tissues of rats induced with the two-kidney, one-clip (2K1C) hypertension model were investigated.