Protective effect of melatonin against ischemia/reperfusion-induced oxidative remote organ injury in the rat

Kacmaz A., User E., Sehirli A., Tilki M., Ozkan S., Sener G.

SURGERY TODAY, cilt.35, sa.9, ss.744-750, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 9
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1007/s00595-005-3027-2
  • Dergi Adı: SURGERY TODAY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.744-750
  • Anahtar Kelimeler: melatonin, ischemia/reperfusion, lipid peroxidation, glutathione, myeloperoxidase, ISCHEMIA-REPERFUSION INJURY, LIPID-PEROXIDATION, MYELOPEROXIDASE ACTIVITY, RADICAL SCAVENGER, MECHANISMS, GLUTATHIONE, LIVER, ANTIOXIDANT, NEUTROPHILS, TISSUE
  • Marmara Üniversitesi Adresli: Evet

Özet

Purpose. Oxygen free radicals are considered to be important components involved in the pathophysiological tissue alterations observed during ischemia/reperfusion (I/R). Based on the potent antioxidant effects of melatonin, we investigated the putative protective role of melatonin against I/R-induced oxidative remote organ injury.