Research Information System
9th International Conference on Materials Science and Nanotechnology for Next Generation, Ankara, Turkey, 22 - 24 September 2022, pp.172, (Summary Text)
Hemoglobin is a tetramer, because of its quaternary structure, it contains grids into which small molecules such as drugs can bind. Recent findings imply that hemoglobin can serve as “super-carrier” of drugs and imaging probes by altering their pharmacokinetics through prolonging their circulation or engineering their biodistribution.
Pyrazole and its derivatives which have been proven to be effective pharmacophores for the treatment of various metabolic disorders. They are the active ingredients of a number of well-known different categories of drugs. The main method used for synthesis of substituted pyrazoles is a cyclocondensation reaction by nucleophilic addition of hydrazine to chalcone compounds containing α,β-unsaturated ketone structures.
In our study, novel pyrazole derivatives with well pharmacokinetic and pharmacodynamic features were synthesized according to their appropriate; “Absorption, Distribution, Metabolism and Excretion” properties. The compounds were synthesized according to main synthesis method, characterized by IR and NMR analysis. Binding interactions between pyrazole derivatives and hemoglobin were investigated by molecular docking and multi-spectroscopic methods. In silico and in vitro studies were evaluated; binding energies and constant, stoichiometry of pyrazoles, their conformations and interactions with hemoglobin and changes in hemoglobin’s secondary structure, quenching mechanisms were determined.