High-dose interferon results in high HBsAg seroclearance in children with chronic hepatitis B infection


Ertem D., Acar Y., Karaa E., Pehlivanoglu E.

TURKISH JOURNAL OF PEDIATRICS, cilt.45, sa.2, ss.123-128, 2003 (SCI İndekslerine Giren Dergi) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Konu: 2
  • Basım Tarihi: 2003
  • Dergi Adı: TURKISH JOURNAL OF PEDIATRICS
  • Sayfa Sayıları: ss.123-128

Özet

Clinical trials for chronic hepatitis B (HBV) infection in children have shown usefulness of interferon alpha 2b (IFN-alpha) in eliminating HBV replication and in improving liver histology. Although it is not-the ultimate goal of the interferon treatment for chronic HBV infection, it has been suggested in adults that HBsAg clearance decreases the likelihood of development of hepatocellular carcinoma, and prolongs, the survival. HBV DNA clearance has been shown to be higher with higher doses of interferon in children, but it was rarely associated with HbsAg clearance.