Effect of angiotensin-converting enzyme inhibition on endothelial function and insulin sensitivity in hypertensive patients

Tezcan H., Yavuz D., Toprak A., Akpinar I., Koc M., Deyneli O., ...More

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, vol.4, no.2, pp.119-123, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 4 Issue: 2
  • Publication Date: 2003
  • Doi Number: 10.3317/jraas.2003.012
  • Journal Name: JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.119-123
  • Keywords: ACE inhibition, endothelial dysfunction, insulin sensitivity, DEPENDENT DIABETES-MELLITUS, ACE-INHIBITION, II ANTAGONISM, DYSFUNCTION, RESISTANCE, DISEASE, MECHANISMS, SYSTEM, VASODILATION, IMPROVEMENT
  • Marmara University Affiliated: Yes

Abstract

Introduction Evidence suggests an association between insulin resistance, hypertension and impaired endothelial function. Studies have shown that insulin resistance precedes the development of hypertension. By improving insulin sensitivity, it may be possible to improve hypertension and the subsequent damage to vessel walls. Some data indicates beneficial effects of angiotensin-converting enzyme (ACE) inhibitors on insulin sensitivity and endothelial function. We aimed to investigate these effects of ACE inhibition in the same group of patients with essential hypertension.