Production of short-chain fatty acids in polyphenol-rich foods by in vitro human digestive system


OĞUZ E., OMURTAG KORKMAZ B. İ., Mizrak Ö. F., Yildirim Servi E., Yaman M.

Acta Pharmaceutica Sciencia, vol.63, no.2, pp.451-463, 2025 (Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 63 Issue: 2
  • Publication Date: 2025
  • Doi Number: 10.23893/1307-2080.aps6329
  • Journal Name: Acta Pharmaceutica Sciencia
  • Journal Indexes: Scopus, EMBASE
  • Page Numbers: pp.451-463
  • Keywords: HPLC, in vitro human digestion, polyphenols, short-chain fatty acids
  • Marmara University Affiliated: Yes

Abstract

The study examines how specific polyphenols influence in vitro human digestion, focusing on their effects on short-chain fatty acids (SCFAs) profiles and antioxidant capacities. Aronia, Cornelian cherry, green tea, and Turkish coffee were digested, and changes in SCFAs and antioxidants were analyzed. Results showed variations in SCFAs levels before and after digestion, with Turkish coffee displaying the lowest acetic acid levels post-digestion (16 ± 0.4 mg/100 g) and green tea showing the highest propionic acid levels (742 ± 19.6 mg/100 g). Cornelian cherry exhibited the greatest increase in butyric acid levels after digestion (4.7 ± 0.12 mg/100 g). Additionally, Turkish coffee showed the highest increase in total phenolic content (TPC) post-digestion, while Cornelian cherry had the highest increase in total antioxidant capacity (TAC). Overall, the findings suggest that polyphenols may positively impact digestion and potentially exhibit prebiotic effects.