Protective effect of chlorogenic acid on renal ischemia/reperfusion injury in rats.


Toprak T., Sekerci C., Aydın H., Ramazanoglu M., Arslan F., Basok B., ...More

Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica, vol.92, 2020 (Journal Indexed in ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 92
  • Publication Date: 2020
  • Doi Number: 10.4081/aiua.2020.2.153
  • Title of Journal : Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica
  • Keywords: Renal ischemia, Oxidative stress, Chlorogenic acid, Rat, ISCHEMIA-REPERFUSION INJURY, IN-VITRO, ANTIOXIDANT, EXTRACTS, DAMAGE

Abstract

Objectives: Ischemia/repetfusion (I/R) injury is a common cause of renal injury and to date, many pharmacological agents have been identified to decrease I/R injury. One of the potential compound that can target I/R injury is chlorogenic acid (CGA). It has potent anti-inflammatory, antibacterial, anti-oxidant, analgesic and antipyretic activities in in vitro experiments and in vivo (mama; models. The aim of the study was to investigate the protective characteristic of CGA on renal I/R injury.