Analysis of the genetic component of systemic sclerosis in Iranian and Turkish populations through a genome-wide association study

Gonzalez-Serna, David; Lopez-Isac, Elena; Yilmaz, Neslihan; Gharibdoost, Farhad; Jamshidi, Ahmadreza; Kavosi, Hoda; Poursani, Shiva; Farsad, Faraneh; Direskeneli, RAFİ; Saruhan-Direskeneli, Guhrer; Vargas, Sofia; Sawalha, Amr; Brown, Matthew; Yavuz, Sule; Mahmoudi, Mahdi; Martin, Javier

doi:10.1093/rheumatology/key281

Analysis of the genetic component of systemic sclerosis in Iranian and Turkish populations through a genome-wide association study

Gonzalez-Serna D., Lopez-Isac E., Yilmaz N., Gharibdoost F., Jamshidi A., Kavosi H., ...Daha Fazla

RHEUMATOLOGY, cilt.58, sa.2, ss.289-298, 2019 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 58 Sayı: 2
Basım Tarihi: 2019
Doi Numarası: 10.1093/rheumatology/key281
Dergi Adı: RHEUMATOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.289-298
Anahtar Kelimeler: SSc, GWAS, Iranian and Turkish populations, risk loci, FUNCTIONAL POLYMORPHISM, SUSCEPTIBILITY LOCI, KAPPA-B, IDENTIFICATION, REVEALS, DISEASE, REGION, RISK, MHC
Marmara Üniversitesi Adresli: Evet

Özet

Objectives. SSc is an autoimmune disease characterized by alteration of the immune response, vasculopathy and fibrosis. Most genetic studies on SSc have been performed in European-ancestry populations. The aim of this study was to analyse the genetic component of SSc in Middle Eastern patients from Iran and Turkey through a genome-wide association study.