Ghrelin alleviates biliary obstruction-induced chronic hepatic injury in rats

Iseri S. O., Sener G., Saglam B., ERCAN F., Gedik N., YEGEN B.

REGULATORY PEPTIDES, vol.146, pp.73-79, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 146
  • Publication Date: 2008
  • Doi Number: 10.1016/j.regpep.2007.08.014
  • Journal Name: REGULATORY PEPTIDES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.73-79
  • Keywords: bile duct ligation, ghrelin, hepatic fibrosis, lipid peroxidation, PROINFLAMMATORY CYTOKINES, ACYLATED PEPTIDE, ACTIVATION, FIBROSIS, MYELOPEROXIDASE, ANGIOGENESIS, CIRRHOSIS, DAMAGE
  • Marmara University Affiliated: Yes

Abstract

Background: Reactive oxygen species and oxidative stress are implicated in hepatic stellate cell activation and liver fibrosis, which are initiated by recruitment of inflammatory cells and by activation of cytokines. Objective: The possible anti-oxidant and anti-inflammatory effects of ghrelin were evaluated in a hepatic fibrosis model in rats with bile duct ligation (BDL).