Ghrelin alleviates biliary obstruction-induced chronic hepatic injury in rats

Iseri S. O., Sener G., Saglam B., ERCAN F., Gedik N., YEGEN B.

REGULATORY PEPTIDES, cilt.146, ss.73-79, 2008 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 146
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.regpep.2007.08.014
  • Dergi Adı: REGULATORY PEPTIDES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.73-79
  • Anahtar Kelimeler: bile duct ligation, ghrelin, hepatic fibrosis, lipid peroxidation, PROINFLAMMATORY CYTOKINES, ACYLATED PEPTIDE, ACTIVATION, FIBROSIS, MYELOPEROXIDASE, ANGIOGENESIS, CIRRHOSIS, DAMAGE
  • Marmara Üniversitesi Adresli: Evet

Özet

Background: Reactive oxygen species and oxidative stress are implicated in hepatic stellate cell activation and liver fibrosis, which are initiated by recruitment of inflammatory cells and by activation of cytokines. Objective: The possible anti-oxidant and anti-inflammatory effects of ghrelin were evaluated in a hepatic fibrosis model in rats with bile duct ligation (BDL).