Discovery of therapeutic agents for prostate cancer using genome-scale metabolic modeling and drug repositioning


Turanli B. , Zhang C., Kim W., Benfeitas R., Uhlen M., Arga K. Y. , ...More

EBIOMEDICINE, vol.42, pp.386-396, 2019 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 42
  • Publication Date: 2019
  • Doi Number: 10.1016/j.ebiom.2019.03.009
  • Title of Journal : EBIOMEDICINE
  • Page Numbers: pp.386-396

Abstract

Background: Genome-scale metabolic models (GEMs) offer insights into cancer metabolism and have been used to identify potential biomarkers and drug targets. Drug repositioning is a time-and cost-effective method of drug discovery that can be applied together with GEMs for effective cancer treatment.