Prolongation of absence seizures and changes in serotonergic and dopaminergic neurotransmission by nigrostriatal pathway degeneration in genetic absence epilepsy rats

Tugba E. K., Medine G. I. O., Ozlem A., Deniz K., ONAT F.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, cilt.213, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 213
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1016/j.pbb.2021.173317
  • Dergi Adı: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Animal Behavior Abstracts, BIOSIS, CAB Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE, Psycinfo, Veterinary Science Database
  • Anahtar Kelimeler: Epilepsy, 6-OHDA, GAERS, Wistar, Medial forebrain bundle, Basal ganglia, NIGRA PARS RETICULATA, BASAL GANGLIA, NETWORK MECHANISMS, WAVE DISCHARGES, MODEL, SPIKE, ADULT, NEURONS, 6-HYDROXYDOPAMINE, LESIONS
  • Marmara Üniversitesi Adresli: Evet

Özet

Objective: Basal ganglia structures play an important role in the pathophysiology of absence epilepsy, known as remote control of absence seizures. We examined the role of the nigrostriatal dopaminergic pathway in absence epilepsy through behavioral and electroencephalography (EEG) parameters, immunohistochemical, and biochemical characteristics of dopamine and serotonin in the genetic absence epilepsy rat model.