Growth Arrest-Specific 6 and Cardiometabolic Risk Factors in Patients with Psoriasis


SÜNBÜL M., Cagman Z., Gerin F., ÖZGEN Z., Durmus E., SEÇKİN GENÇOSMANOĞLU D., ...Daha Fazla

CARDIOVASCULAR THERAPEUTICS, cilt.33, sa.2, ss.56-61, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 2
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1111/1755-5922.12112
  • Dergi Adı: CARDIOVASCULAR THERAPEUTICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.56-61
  • Anahtar Kelimeler: Atherosclerosis, Growth Arrest-Specific 6, Psoriasis, Risk Factors, SYSTEMIC-LUPUS-ERYTHEMATOSUS, K-DEPENDENT PROTEINS, SMOOTH-MUSCLE-CELLS, TAM RECEPTORS, CARDIOVASCULAR RISK, DISEASE-ACTIVITY, VASCULAR CALCIFICATION, PLASMA-CONCENTRATIONS, ARTERIAL STIFFNESS, ENDOTHELIAL-CELLS
  • Marmara Üniversitesi Adresli: Evet

Özet

ObjectivesAn increased risk for cardiovascular disease with psoriasis has been reported. Growth Arrest-Specific 6 (GAS6) amplifies pro-inflammatory endothelial cell activation via TAM receptors. However, it also inhibits inflammation by multiple mechanisms including phagocytosis. The objective of this study was to investigate whether plasma GAS6 levels are associated with conventional cardiometabolic (CM) risk factors in patients with psoriasis.