The effect of pentoxifylline on intestinal ischemia/reperfusion injury

Sener G., Akgun U., Satiroglu H., Topaloglu U., Keyer-Uysal M.

FUNDAMENTAL & CLINICAL PHARMACOLOGY, cilt.15, sa.1, ss.19-22, 2001 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 1
  • Basım Tarihi: 2001
  • Dergi Adı: FUNDAMENTAL & CLINICAL PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.19-22
  • Anahtar Kelimeler: glutathione, intestinal ischemia, lipid peroxidation, myeloperoxidase, pentoxifylline, reperfusion, REPERFUSION INJURY, ISCHEMIA, SUPEROXIDE, RADICALS, RATS
  • Marmara Üniversitesi Adresli: Hayır

Özet

The small intestine is highly sensitive to oxygen free radical-induced injury. Post-ischemic intestinal tissue damage appears to be due to the formation of oxygen radicals. Free radical initiated lipid peroxidation (LP) following intestinal ischemia/reperfusion (I/R) may disrupt mucosal integrity, Indirectly, the radicals trigger the accumulation of neutrophils within the affected tissue, initiating inflammatory processes that lead to severe mucosal lesions.