The effect of pentoxifylline on intestinal ischemia/reperfusion injury


Sener G., Akgun U., Satiroglu H., Topaloglu U., Keyer-Uysal M.

FUNDAMENTAL & CLINICAL PHARMACOLOGY, vol.15, no.1, pp.19-22, 2001 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 1
  • Publication Date: 2001
  • Title of Journal : FUNDAMENTAL & CLINICAL PHARMACOLOGY
  • Page Numbers: pp.19-22
  • Keywords: glutathione, intestinal ischemia, lipid peroxidation, myeloperoxidase, pentoxifylline, reperfusion, REPERFUSION INJURY, ISCHEMIA, SUPEROXIDE, RADICALS, RATS

Abstract

The small intestine is highly sensitive to oxygen free radical-induced injury. Post-ischemic intestinal tissue damage appears to be due to the formation of oxygen radicals. Free radical initiated lipid peroxidation (LP) following intestinal ischemia/reperfusion (I/R) may disrupt mucosal integrity, Indirectly, the radicals trigger the accumulation of neutrophils within the affected tissue, initiating inflammatory processes that lead to severe mucosal lesions.