Assessing mental health in children and adolescent with MTHFR polymorphisms: psychiatric disorders, executive functioning, and symptom profile in a Turkish clinical sample

Poyraz Findik O. T., Murat D., Gumustas F., Rodopman Arman A., Ozer I.

CHILDRENS HEALTH CARE, cilt.50, sa.2, ss.220-237, 2021 (SSCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 50 Sayı: 2
  • Basım Tarihi: 2021
  • Doi Numarası: 10.1080/02739615.2021.1871616
  • Dergi Adı: CHILDRENS HEALTH CARE
  • Derginin Tarandığı İndeksler: Social Sciences Citation Index (SSCI), Scopus, Academic Search Premier, ASSIA, Child Development & Adolescent Studies, CINAHL, EMBASE, Psycinfo
  • Sayfa Sayıları: ss.220-237
  • Anahtar Kelimeler: attention-deficit hyperactivity disorder, executive function, genetics, mental health, Methylenetetrahydrofolate reductase (NADPH2)
  • Marmara Üniversitesi Adresli: Evet

Özet

This study investigated behavioral phenotype, executive functions profile, and the existence of comorbid psychiatric disorders in children and adolescents with methylenetetrahydrofolate reductase (MTHFR) polymorphisms admitted to pediatric metabolism outpatient clinic. Internalizing problems, especially somatic complaints were common in patients with MTHFR. More than half of the cases had emotional control and initiating problems as executive function deficits. Attention-deficit/hyperactivity disorder was the most common psychiatric diagnosis, followed by anxiety disorder. Current findings emphasize that health care providers should be aware of the mental health needs of cases with MTHFR polymorphism in order to make plans of integrative physical and mental health care.