Response Assessment With Molecular Characterization of Circulating Tumor Cells and Plasma MicroRNA Profiling in Patients With Locally Advanced Breast Cancer During Neoadjuvant Chemotherapy


AKKİPRİK M. , Koca S., UĞURLU M. Ü. , Ekren R., Peker Eyüboğlu İ., Alan Ö., ...Daha Fazla

CLINICAL BREAST CANCER, cilt.20, sa.4, ss.332-346, 2020 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 20 Konu: 4
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1016/j.clbc.2020.02.006
  • Dergi Adı: CLINICAL BREAST CANCER
  • Sayfa Sayıları: ss.332-346

Özet

Peripheral blood samples from 36 patients with locally advanced breast cancer who had undergone neoadjuvant chemotherapy were collected for circulating tumor cell (CTC) and plasma microRNA (miR) analysis. Pretreatment CTC and ALDH1 positivity (P = .0245) correlated, with miR-146b-5p and miR-199a-5p accompanied by CTC positivity. CTC and miR profiling of serial samples during neoadjuvant chemotherapy appears to be a very useful in predicting cure and clinical course.