Response Assessment With Molecular Characterization of Circulating Tumor Cells and Plasma MicroRNA Profiling in Patients With Locally Advanced Breast Cancer During Neoadjuvant Chemotherapy

Akkiprik, MUSTAFA; Koca, Sinan; Uğurlu, MUSTAFA; Ekren, Rüçhan; Peker Eyüboğlu, İREM; Alan, Özkan; Erzik, CAN; Güllü Amuran, GÖKÇE; Telli, Tuğba; Güllüoğlu, MAHMUT; Sezerman, Uğur; Yumuk, PERRAN

doi:10.1016/j.clbc.2020.02.006

Response Assessment With Molecular Characterization of Circulating Tumor Cells and Plasma MicroRNA Profiling in Patients With Locally Advanced Breast Cancer During Neoadjuvant Chemotherapy

Atıf İçin Kopyala

Akkiprik M., Koca S., Uğurlu M. Ü., Ekren R., Peker Eyüboğlu İ., Alan Ö., ...Daha Fazla

CLINICAL BREAST CANCER, cilt.20, sa.4, ss.332-346, 2020 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 20 Sayı: 4
Basım Tarihi: 2020
Doi Numarası: 10.1016/j.clbc.2020.02.006
Dergi Adı: CLINICAL BREAST CANCER
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE
Sayfa Sayıları: ss.332-346
Anahtar Kelimeler: Breast cancer, CTCs, EMT, NACT, Stem cell marker, DIFFERENTIAL EXPRESSION ANALYSIS, RNA, BIOMARKER, MIRNAS, DIAGNOSIS
Marmara Üniversitesi Adresli: Evet

Özet

Peripheral blood samples from 36 patients with locally advanced breast cancer who had undergone neoadjuvant chemotherapy were collected for circulating tumor cell (CTC) and plasma microRNA (miR) analysis. Pretreatment CTC and ALDH1 positivity (P = .0245) correlated, with miR-146b-5p and miR-199a-5p accompanied by CTC positivity. CTC and miR profiling of serial samples during neoadjuvant chemotherapy appears to be a very useful in predicting cure and clinical course.