Response Assessment With Molecular Characterization of Circulating Tumor Cells and Plasma MicroRNA Profiling in Patients With Locally Advanced Breast Cancer During Neoadjuvant Chemotherapy

Akkiprik M., Koca S., Uğurlu M. Ü., Ekren R., Peker Eyüboğlu İ., Alan Ö., ...More

CLINICAL BREAST CANCER, vol.20, no.4, pp.332-346, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 4
  • Publication Date: 2020
  • Doi Number: 10.1016/j.clbc.2020.02.006
  • Journal Name: CLINICAL BREAST CANCER
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE
  • Page Numbers: pp.332-346
  • Keywords: Breast cancer, CTCs, EMT, NACT, Stem cell marker, DIFFERENTIAL EXPRESSION ANALYSIS, RNA, BIOMARKER, MIRNAS, DIAGNOSIS
  • Marmara University Affiliated: Yes

Abstract

Peripheral blood samples from 36 patients with locally advanced breast cancer who had undergone neoadjuvant chemotherapy were collected for circulating tumor cell (CTC) and plasma microRNA (miR) analysis. Pretreatment CTC and ALDH1 positivity (P = .0245) correlated, with miR-146b-5p and miR-199a-5p accompanied by CTC positivity. CTC and miR profiling of serial samples during neoadjuvant chemotherapy appears to be a very useful in predicting cure and clinical course.