Oxytocin as a protective agent in cisplatin-induced ototoxicity


Bilmez Z. E. B. , Aydin S., Sanli A., Altintoprak N., Demir M. G. , Erdogan B. A. , ...More

CANCER CHEMOTHERAPY AND PHARMACOLOGY, vol.77, no.4, pp.875-879, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 77 Issue: 4
  • Publication Date: 2016
  • Doi Number: 10.1007/s00280-016-2978-x
  • Title of Journal : CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • Page Numbers: pp.875-879

Abstract

Cisplatin is a potent chemotherapeutic drug with serious side effects such as ototoxicity which is characterized by irreversible, bilateral, progressive sensorineural hearing loss. Oxytocin, which is a well-known hormone secreting during pregnancy, has antioxidant and antiinflammatory effect. Our study aims to test and compare the effect of intratympanic (IT) and intraperitoneal (IP) oxytocin on cisplatin ototoxicity with DPOAE.