Measurements of serum procollagen-III peptide and M30 do not improve the diagnostic accuracy of transient elastography for the detection of hepatic fibrosis in patients with nonalcoholic fatty liver disease

ERGELEN R., Akyuz U., Aydin Y., EREN F., YILMAZ Y.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY, cilt.27, sa.6, ss.667-671, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 6
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1097/meg.0000000000000342
  • Dergi Adı: EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.667-671
  • Anahtar Kelimeler: accuracy, biomarkers, fibroscan, fibrosis, nonalcoholic fatty liver disease, transient elastography, STEATOHEPATITIS, VALIDATION, STEATOSIS, CIRRHOSIS, BIOPSY, NAFLD, NASH
  • Marmara Üniversitesi Adresli: Evet

Özet

Background Transient elastography (TE) has recently emerged as an accurate noninvasive imaging method for the diagnosis of liver fibrosis in nonalcoholic fatty liver disease (NAFLD). Here, we tested whether adding serum measures of serum procollagen-III peptide (PIIIP) and caspase-cleaved cytokeratin 18 fragment (M30) to TE could improve its diagnostic accuracy in patients with biopsy-proven NAFLD.