Research Information System
Medicine Science, vol.14, no.2, pp.521-529, 2025 (Peer-Reviewed Journal)
This study aimed to investigate the performance of prognostic nutritional index (PNI) to predict the respiratory-related hospitalization (RRH) risk over the course of a year in bronchiectasis patients. A total of 194 bronchiectasis patients were retrospectively evaluated in terms of chronic bacterial colonization and the bronchiectasis pattern, laboratory findings, FACED score and PNI on the day of presentation to the outpatient clinic in stable period, while patients were further followed up for RRH events over the course of a year. RRH was significantly more common in patients with vs. those without comorbid chronic obstructive pulmonary disease (75.7 vs. 35.8%, p<0.001) and previous tuberculosis history (70.0 vs. 44.4%, p=0.002). PNI values were significantly lower (46.9 vs. 55.9, p<0.001) in patients with vs. those without RRH. PNI was found to be a potential marker of hospitalization risk in bronchiectasis patients at a cut-off value of <50.55 (sensitivity: 90.5%, specificity: 69.7%) The decrease in PNI (OR, 0.782, 95% CI: 0.727-0.840, p<0.001) was found to independently predict the hospitalization risk. In conclusion, PNI seems to be a valuable marker in identifying the patients at risk of RRH, which can simply be calculated based on serum albumin level and peripheral lymphocyte count without needing clinical evaluation.