Right-lobe Liver Transplant From Donors With Gilbert Syndrome

Demirbas T., PİŞKİN T., Dayangac M., Yaprak O., Akyildiz M., Tokat Y., ...Daha Fazla

EXPERIMENTAL AND CLINICAL TRANSPLANTATION, cilt.10, sa.1, ss.39-42, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 1
  • Basım Tarihi: 2012
  • Doi Numarası: 10.6002/ect.2011.0063
  • Dergi Adı: EXPERIMENTAL AND CLINICAL TRANSPLANTATION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.39-42
  • Anahtar Kelimeler: Living-donor liver transplantation, Living-donor, Right hepatectomy, Gilbert syndrome, Hyperbilirubinemia, UNCONJUGATED HYPERBILIRUBINEMIA, EXTENDED CRITERIA, SINGLE-CENTER, EXPERIENCE, GRAFTS
  • Marmara Üniversitesi Adresli: Evet

Özet

Objectives: Donor safety is one of the most important aspects of living-donor liver transplant. The preoperative evaluation of candidates for such transplants essentially starts with serologic and biochemical analyses. However, some potential liver donors with normal liver function test results may have isolated mild hyperbilirubinemia (serum indirect bilirubin level > 20.5 mu mol/L [1.2 mg/dL]). Gilbert syndrome is an autosomal recessive condition that is a common cause of nonhemolytic unconjugated hyperbilirubinemia, and its prevalence is 3% to 10% in the healthy US population. Mild hyperbilirubinemia episodes are expected in people with Gilbert syndrome when they are exposed to physical stress, such as operative intervention or low energy intake. The liver morphologic findings of these individuals are normal; however, there is a debate on the use of people with Gilbert syndrome as living-liver donors. The purpose of this study was to assess the results of right-lobe living-donor hepatectomy of liver donors with Gilbert syndrome.