Akademik Veri Yönetim Sistemi
Applications of Chemistry in Nanosciences and Biomaterials Engineering NanoBioMat 2025 – Sumer Edition, Bucuresti, Romanya, 25 - 27 Haziran 2025, ss.82, (Özet Bildiri)
Research shows that skin cancer is the most common type of cancer diagnosed in the world in 2020. Although melanoma, the most aggressive of skin cancers, is a rare disease in the world, its contribution to the increase in skin cancer death rates is too significant to be ignored. The development of melanoma is a complex and multi-stage process mediated by various cellular, biochemical and molecular changes. The disease originates from melanocytes, which are responsible for the production of melanin, which gives the skin its color. Factors such as fair skin, intermittent exposure to strong sunlight, blistering sunburns, especially during childhood, and a family history of melanoma are some of the risk factors for the disease [1]. The increasing incidence of melanoma and its difficult treatment have led to an increase in interest in natural compounds that may hold promise. Fucoidan (FUC), obtained from brown algae, is a class of sulfated polysaccharides that offer different biological activities such as antitumor, antiviral, anti-inflammatory, immunomodulatory and anti-angiogenic potential, which are also used in the treatment of melanoma [2]. The anti-cancer properties of fucoidan have been demonstrated in vivo and in vitro in various types of cancer, especially skin cancer, colorectal cancer and breast cancer [3]. This study intends to demonstrate a novel method of treating skin cancer through the use of biomaterials on the creation of a scaffold based on polylactic acid/keratin metakrilat/fucoidan (PLA/KerMA/FUC). The morphological possessions were performed with a scanning electron microscope (SEM). Fourier transformed infrared spectroscopy (FTIR) was used to observe the chemical interactions between the components. The X-ray diffraction (XRD) was used to analyse the structural properties of the scaffolds. The thermal properties of the scaffolds were determined with differential scanning calorimetry (DSC). The mechanical properties of the scaffolds were detected with tensile testing.